{"type":"standard","title":"ANA-12","displaytitle":"ANA-12","namespace":{"id":0,"text":""},"wikibase_item":"Q25100908","titles":{"canonical":"ANA-12","normalized":"ANA-12","display":"ANA-12"},"pageid":49040100,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/6/62/ANA-12_structure.svg/330px-ANA-12_structure.svg.png","width":320,"height":283},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/6/62/ANA-12_structure.svg/362px-ANA-12_structure.svg.png","width":362,"height":320},"lang":"en","dir":"ltr","revision":"1234861798","tid":"b1d26703-4380-11ef-a263-803aa802b70a","timestamp":"2024-07-16T14:35:49Z","description":"Chemical compound","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/ANA-12","revisions":"https://en.wikipedia.org/wiki/ANA-12?action=history","edit":"https://en.wikipedia.org/wiki/ANA-12?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:ANA-12"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/ANA-12","revisions":"https://en.m.wikipedia.org/wiki/Special:History/ANA-12","edit":"https://en.m.wikipedia.org/wiki/ANA-12?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:ANA-12"}},"extract":"ANA-12 is a selective, small-molecule non-competitive antagonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF). ANA-12 was originally discovered and developed by Cazorla M. and colleagues at Université Paris and Inserm in 2011. The compound crosses the blood-brain-barrier and exerts central TrkB blockade, producing effects as early as 30 minutes and as long as 6 hours following intraperitoneal injection in mice. It blocks the neurotrophic actions of BDNF without compromising neuron survival.","extract_html":"
ANA-12 is a selective, small-molecule non-competitive antagonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF). ANA-12 was originally discovered and developed by Cazorla M. and colleagues at Université Paris and Inserm in 2011. The compound crosses the blood-brain-barrier and exerts central TrkB blockade, producing effects as early as 30 minutes and as long as 6 hours following intraperitoneal injection in mice. It blocks the neurotrophic actions of BDNF without compromising neuron survival.
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